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Exploring aptamer as biomimetic targeting ligands for nano-delivery The size-based BBB permeability limitation of the conventional antibody targeting specific ligand (protein) on the surface of the glioma cells/BCECs/GSCs reduces their therapeutic benefits

McCormick, J

A differential gene analysis had shown 139 protein-based targets which had 67 upregulated and 72 downregulated in the DCM mouse model (109)

In contrast, in ethanol-exposed Grx1 -deficient mice, accumulation of FAS-SSG drives hepatocyte apoptosis through dysregulation of NF-B and AKT serine/threonine kinase 1 (AKT1) signaling 47