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Subsequent trials conducted in ICUs used an approach identical with or similar to PRORATA, but PCT levels for starting and stopping thresholds varied, patient populations were also heterogeneous with medical, surgical, or mixed populations treated for different types of infections, and therefore the overall interpretation and implementation of PCT-guided AB therapy in ICU setting remains challenging

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The plasma EA3571 concentrations decreased with t 1/2 less than 1.0 hour after reaching the peak concentration in SAD parts

Along with this limitation, current approaches are labor intensive, highly dependent on expensive growth factors and not amenable to scaling

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