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Here we have reviewed current pharmacological methods of targeting SAM production via MAT2A inhibition and direct PRMT5 inhibition (both of which reduce PRMT5-specific methylation reactions) and reported evidence for and against the selectivity of these treatments for MTAP -negative tumours

Researchers continue to explore a range of influences, including prenatal or medical factors such as viral infections, certain medications, environmental exposures, or complications during pregnancy

10.1038/s41419-019-1899-0 30 TsaiY.XiaC.SunZ

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