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Amy Yasko, the most well tolerated active form of Vitamin B12 Sublingual for folks seems to be hydroxy B12. All of the genetic combinations she lists below should be able to tolerate Vitamin B12 Sublingual in the form of hydroxy B12 (which is why our methylation protocol suggests hydroxy B12 as the Vitamin B12 Sublingual form to begin with)

Common Side Effects When side effects occurred, they were typically mild, transient, and similar in frequency to placebo groups: Reported Adverse Effects Most Common (occurring in small percentage of participants): Mild to moderate headaches (most frequently reported, often resolving with continued use) Injection site reactions (minor redness, swelling, or irritation at injection site) Gastrointestinal effects (particularly at higher oral doses: mild nausea, diarrhea, flatulence) Fatigue (reported occasionally during initial adaptation period) Rare Events: One case of chest tightness was deemed possibly related to treatment in safety trials