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The integration of data from lipidomics and mass spectrometry-based metabolomics platforms in future studies, as well as inclusion of several confounding variables, such as body mass index, diet, and lifestyle factors, would definitely help to better unravel the mechanistic aspect of the drug response

Besides, xanthine oxidase plays a vital role in the production of ROS, which shows an important role in the development of DM and associated complications (Fidler et al., 2017)

In a meta-analysis involving 25 controlled trials and 791 individuals, SAMe offered statistically significant support for positive mood believed to be due to its support for neurotransmitter monoamine synthesis and function, including dopamine and serotonin

However, excessive consumption of serine can be neurotoxic, so its use requires caution