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It plays a central role in cellular metabolism, DNA repair, and overall cellular resiliency. As a key regulator of energy production and cellular maintenance, NAD+ enables cells to efficiently convert nutrients into energy and respond to physiological stressfunctions that are fundamental to healthy aging

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The limited success of drugs used in neurological disorders has led to the exploration of optimized drug delivery systems to overcome this barrier (Cecchelli et al., 2007)

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In doing so, the enzyme loses its capacity to bind NADH by alterations in its catalytic site and, instead, transfers electrons from O 2 , thereby generating O 2 - [82]