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Second, and more importantly, protein aggregates can trigger immune responses

The optimal administration schedule and dosage vary depending on the desired therapeutic outcome

Appetite 172 , 105965 (2022)

In murine models, NNMT knockdown did not induce the accumulation of NAM in livers and adipose tissues, nor did it cause significant alterations in the intracellular levels of NAD + in hepatocytes (Kraus et al., 2014