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Gorbunova V., Rezazadeh S., Seluanov A., Cell 2016, 165, 1312

Nutr Rev 72:627637 Vincent JB, Sack DA, Roffman M, Finch M, Komorowski JR (2003) The potential value and toxicity of chromium picolinate as a nutritional supplement, weight loss agent and muscle development agent

A consistent feature of HD in both human brain tissue and animal models is the significant loss of the astrocyte-specific glutamate transporter GLT-1 (also known as EAAT2), which is essential for the clearance of extracellular excitatory glutamate [294,296-299]

Unlike the anti-inflammatory effect inside the cell, it seems to play a more immune-enhancing role outside the cell [41, 42]

Notably, melatonin increases p53 expression through the PI3K/Akt/mTOR signaling pathway, which plays a significant role in tumor suppression