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Particular concerns exist for those with: Type 2 diabetes or pre-diabetes , due to opposing and unpredictable glycaemic effects Cardiovascular disease , given the potential for heart rate changes and fluid retention associated with GH Active malignancy , as GH stimulation is contraindicated in this setting Pregnancy or breastfeeding neither agent should be used during pregnancy or whilst breastfeeding

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27, 699 (2019), Abstract Metformin-sensitized NSCLC cells to osimertinib via AMPK-dependent autophagy inhibition: Chen, H., Lin, C., et al