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According to studies, icariin improves motor function, lessens microglial M1 activation and neuronal death, and inhibits the JNK, p38 MAPK, and NF-B pathways to minimize the generation of ROS and inflammatory cytokines brought on by LPS (Zeng, et al., 2010) (Table 1)

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It is crucial to identify the core targets that lead to pathological changes from quantitative to qualitative changes during this process, and the above preventive interventions, sleep improvement, physical exercise, dietary regulation, and social intervention, may prolong or reverse the subclinical pathological stage (Fig

Thermo Scientific, Rockford, IL, USA)