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In mouse embryonic fibroblasts, the elevation of CHAC1 protein expression following As III exposure is negatively regulated by the Tribbles homolog 3 (TRIB3), which limits CHAC1s pro-death potential (rd et al., 2016)

Natelson, B.H., Vu, D., Copla,n J.D., Mao, X., Blate, M., Kang, G., Soto, E., Kapusuz, T

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However, it is not clear whether the trial was unsuccessful because pirfenidone was not effective at reducing collagen deposition or because collagen type I is not an effective drug target in pNF