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Luminal solutes and ions can pass across the IEB via two main routes: the transcellular pathway or the paracellular pathway

J Pharmacol Exp Ther 2014;351:390-402

10.1016/j.tibs.2024.11.004 125 PolierS.DragovicZ.HartlF

Many intrinsic and extrinsic factors, such as neurotrophic factors, transcription factors, cell cycle regulators, cell proliferation, neurogenic niche and differentiation into mature neurons, play an important role in the pathomechanism of AD