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One study suggested that these findings indicate coppers potential local effect on the pathogenesis of OSF(Saikia and Vaidehi, 1983

Furthermore, melatonin can be transferred by hydrogen atoms (hydrogen atom transfer, HAT), proton-coupled electron transfer (proton-coupled electron transfer, PCET), free radical addition, substances (radical adduct formation, RAF), single-electron transfer (SET), sequential electron-proton transfer (SEPT), and other mechanisms that directly remove peroxy groups (peroxyl radical, ROO), hydroxyl radical (OH), OO groups (nitric oxide, NO), and other free radicals (58)

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For instance, curcumin inhibited the generation of glutamate, OH - , prostaglandins and activation of pro-inflammatory cytokines in rats hypothalamus [379]