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The conformational preferences were determined experimentally using either the cysteine accessibility experiments or by comparing binding affinity to specific mutants that shift the conformational state

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Systemic and topical administration work through different pathways, potentially complementing each other

Let's take a closer look at these features: Follicle Contraction: During the catagen phase, the hair follicles contract, causing the hair shaft to detach from the blood supply that nourishes it