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Tofacitinib, baricitinib, and ruxolitinib are among the JAK inhibitors currently investigated to determine whether they can treat COVID-19 (e.g., NCT-04332042, NCT-04348695, NCT-04321993, and NCT-04348695) (Peterson et al., 2020)

Genetic susceptibility plays a key role

Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria

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Emerging antioxidants, combined with cutting edge delivery systems and personalized medicine approaches, represent a promising evolution in managing oxidative stress related male infertility