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Moreover, a unique point mutation of PSMB5 (gene encoding the proteasome 5 subunit) alleviates fatal ER stress, promoting bortezomib resistance in MM cells (122)

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Here we review the evidence for white matter abnormalities in AD with a focus on myelin and oligodendrocytes, the only source of myelination in the central nervous system, and discuss the relationship between white matter changes and the hallmarks of Alzheimers disease