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Inhibition of RNA-dependent protein kinase (PKR) leasds to cancer cell death and increases chemosensitivity

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Cochrane Database Syst Rev (2012) 9:CD006616.10.1002/14651858.CD006616.pub2 7 FraternaleACrinelliRCasabiancaAPaolettiMFOrlandiCCarloniEet alMolecules altering the intracellular thiol content modulate NF-kB and STAT-1/IRF-1 signalling pathways and IL-12 p40 and IL-27 p28 production in murine macrophages

Sulforaphane inhibited the nociceptive responses, anxiety-and depressive-like behaviors associated with neuropathic pain and improved the anti-allodynic effects of morphine in mice

Changes in sleep architecture included increased lighter sleep stages (S1 and S2), decreased deep sleep stages (S3, S4), and REM sleep, as well as delayed REM sleep onset