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Kadry MO, Abdel-Megeed RM

Bloodletting Bloodletting, encompassing both standalone bloodletting and isovolemic hemodilution, serves as a palliative measure to reduce polycythemia and improve some symptoms of CMS

Notably, we have demonstrated in an HD mouse model that mitochondrial dysfunction leads to enhanced release of mtDNA into the cytosol, which primes innate immune activation via the cGASSTING pathway