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Although these three isoforms share similar bioactive regions and can bind to the same type I and type II TGF- receptor complexes, TGF- is widely recognized as the most potent pro-fibrotic factor, primarily acting through the Smad (Smad-2, 3, 4, etc.) signaling pathway to promote fibrosis development (38, 39)

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More specifically, in the periphery of aged people there is a rise in CD45R0 + memory T cells and a reduction in CD45RA + nave T cells [284]

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With the participation of various enzymes, the metabolic pathway of glutathione becomes complicated when it involves in environmental stress