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P.et al (2006)

44,45 IRE (iron response element) /IRP (iron regulatory protein) axis plays critical role in maintaining iron homeostasis through posttranscriptional regulation of iron-related genes

Further experiments showed that NMN can increase SIRT3 activity and reduce age-related acetylation in Sod2 in mice

Conclusions We have identified vitamin deficiencies, antioxidant deficiencies, and the reduced function gene polymorphisms of MTHFR as common risk factors for hyperhomocysteinemia, neurotrophic factor depletion, and DR