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Neuro-invasion of SARS-CoV-2 occurs via transcribrial (nose) route with damage to olfactory mucosa, and olfactory nerves, ultimately manifesting into anosmia (loss of smell) 197,198

First, the valve flaps may be oversized and thickened

Also, oral administration increases the risk of systemic side effects

doi: 10.1093/ajcn/86.4.1073

This suggests that the effects BCAA consumption on insulin sensitivity likely depend on physiological context (energy and substrate requirements) and underlying (subtle) co-morbidities