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A systematic review of 22,790 prisoners across 12 countries has estimated that among incarcerated men, about 3.7% had psychotic disorder, 10% had major depression, and up to 65% had a personality disorder

Baseline hormone panels are drawn before prescribing, and follow-up appointments occur every 4 to 8 weeks to track progress and adjust dosing

The primary first-line therapeutic agent is methotrexate , a folate antimetabolite that suppresses the abnormal immune response and halts disease progression

In a study on patients with epilepsy, it has been reported that there was no significant difference in the GSH level when compared to healthy individuals 28