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The new plasmids necessary to reproduce the work have been deposited at Addgene ( Source data are provided with this paper

Tamoxifen binds to ER, the ER/tamoxifen complex recruits other proteins known as co-repressors, and the complex then binds to DNA to modulate gene expression

Hair follicles are present around the lower end of the hair, called hair roots, which help keep the hair anchored to the scalp

Regarding small molecule inhibitors targeting NNMT, challenges include the identification of efficient and selective inhibitors with robust in vivo activity (Barrows et al., 2022)