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Healthy mice wounds were treated with PBS as the blank control (BC group)

10.1096/fj.11-197137 FASEB J

Clinical trials have also demonstrated WAs safety and tolerability, including a Phase I trial in osteosarcoma patients at doses up to 216 mg

We propose a stratified decision framework anchored in DCCD state, lipid-droplet/PLIN2 phenotype, ferroptosis sensitivity, and HIF activity, and discuss the emerging roles of radiopathomics (e.g., CT HUPLIN2 coupling) and circulating metabolic fingerprints in companion diagnostics

For instance, by leveraging immunomagnetism or the interaction between specific proteins and lipids, drugs can be guided to specifically target specific cells or tissues