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However, there was no evidence of further reduction of ROS generation with the addition of ascorbic acid (Supplementary Fig

Moreover, it has been shown that the activation of the glutamate-NO-cGMP-PKG-PDE pathway is necessary for the re-establishment, induction, and adequate maintenance of LTP in the hippocampus of hyperammonemic rats (Monfort et al., 2007)

Taking into account the pathogenic mechanisms of ALS, the new therapeutic strategies have as the main goal to activate the metabolic pathways related to the mitochondria, production of energy and increase the antioxidant defense levels

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Although inflammation is important in both diseases, the inflammatory response in COPD is markedly different from that in asthma