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Nakladal D, Lambooy SPH, Mith S et al (2022) Homozygous whole body Cbs knockout in adult mice features minimal pathology during ageing despite severe homocysteinemia

APE1 is therefore considered to be neuroprotective because of its dual role in oxidative DNA damage and redox regulation (Copped, APE1 is upregulated in motor neurons of ALS patients compared to age-matched controls (Shaikh and Martin, 2002)

In 11 out of 15 charts, family members were involved in the decision making process, and this was documented in the ACP referral

6 Conclusion and Perspective Delayed wound healing of diabetic ulcers involves multiple pathological mechanisms, including peripheral nerve and blood vessel injury and increased inflammation cascades

Although all the included studies showed the same direction of effect, we encountered high heterogeneity in our primary outcomes