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Our study indicates the importance of IGF-1R in maintaining a balance between cell survival and apoptosis of GNE deficient cells that are of interest to be explored further for drug design in disorders associated with sialic acid deficiency

FDA compounding status

99 B12 deficiency in infants can cause anaemia, abnormal skin and hair development, convulsions, failure to thrive, mental developmental delay and possibly abnormal movements, and direct supplementation of the infant is recommended in such cases

These combinations deserve to be further studied for possible clinical applications, particularly for inhaled formulations that would enable the high NALC concentration to be reached at the infection site in cases with pulmonary infections while minimizing systemic toxicity

Toxins 17:399