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Oral : administration by mouth Intrathecal : infusion into the fluid surrounding the brain and spinal cord Intra-arterial (IA) : injection into an artery Intraperitoneal (IP) : injection into the abdominal cavity Intravesical : administration directly into the urinary bladder through a catheter Intramuscular : injection into a muscle Topical : application to the skin Subcutaneous : injection under the skin 4 Chemotherapy Dose Optimization Conventional chemotherapy regimens are typically calibrated to deliver the maximum tolerable dose of cytotoxic drugs (Baszkowsky 2012

For a maximum of 60 s, the rats were permitted to roam at 30, 50, and 70 cm from the end of the beam that contained the training bulb

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