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ReichardP.EliassonR.IngemarsonR.ThelanderL.2000Cross-talk between the allosteric effector-binding sites in mouse ribonucleotide reductase

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Macrophage Cell Death and Efferocytosis Influence Plaque Stability The necrotic core results from a combination of accelerated macrophage death and impaired efferocytosis (receptor-mediated phagocytosis of apoptotic cells) (Figure 5) (171,172)

Mechanistically, Na 2 S 4 increases the expression of SIRT1, reducing the phosphorylation and acetylation levels of NF-B p65 and STAT3 and inhibiting the Bax, cleaved caspase-3, and cleaved PARP protein expressions to reduce apoptosis