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To generate AdipoQ-CreERT2 x p53-Lox mice, female mice heterozygous for the CRE-transgene and homozygous for loxP-flanked allele were bred with male mice homozygous for loxP-flanked allele starting at the age of 10 weeks

This modulation can reverse the pathological expression of genes associated with cancer progression, thereby potentially restoring tissue integrity and health 13