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This conservative approach treats GHK-Cu as a periodic regenerative boost rather than ongoing maintenance

Campagna R, Mateuszuk , Wojnar-Lason K, Kaczar P, Tworzydo A, Kij A, Bujok R, Mlynarski J, Wang Y, Sartini D (2021a) Nicotinamide N-methyltransferase in endothelium protects against oxidant stress-induced endothelial injury

Anti-BCMA novel therapies for multiple myeloma

doi:10.1007/s00125-002-0862-1 51

This could potentially result in a different outcome for cell lines and primary cells, if the original NA, but not the reactive metabolites can cross cell membranes, or if highly reactive metabolites can already react with media or membrane components