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Description

These limitations may be partially overcome by conditional reprogramming with the Rho associated coiled-coil containing protein kinase inhibitor, Y27632, or bone morphogenetic protein/transforming growth factor, beta 1 antagonists that repress differentiation and extend culture life

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H.FrlichJ

doi: 10.1007/s40279-021-01585-9 155

This suggests that while machine perfusion can be a beneficial tool in enhancing graft viability, the choice between normothermic and hypothermic methods may be less critical