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Discovery of hydroxytriazole as a potential glyoxalase-I inhibitor utilizing computer-aided drug design techniques

DOI: 10.1073/pnas.1306182110 Ding, N., Yu, R.T., Subramaniam, N., Sherman, M.H., Wilson, C., Rao, R., Leblanc, M., Coulter, S., He, M., Scott, C., Lau, S.L., Atkins, A.R., Barish, G.D., Gunton, J.E., Liddle, C., Downes, M., Evans, R.M

-Tocopherol was also linked to lower NFT accumulation in brain regions affected in early Braak stages, such as the hippocampus, amygdala, and entorhinal cortex but not in the later-affected brain regions [12] In APOE4 carriers (i.e., individuals with at least one copy of the 4 allele of the apolipoprotein E (APOE) gene, a well-established genetic risk factor for late-onset AD), higher dietary intake of -tocopherol was significantly associated with a slower rate of cognitive decline [46]

Do you struggle to eat organ meat

Ute Braun-Munzinger, erfahrene Allgemeinrztin mit naturheilkundlichem Schwerpunkt, kombiniert seit ber 30 Jahren Schulmedizin mit Traditioneller Chinesischer Medizin, Ernhrungstherapie und weiteren Methoden