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We know that long-duration proton pump inhibitor (PPI) use is often associated with lower magnesium levels and deficiency. Meacham says

doi: 10.1111/bph.13129 158 NegriS.FarisP.Berra-RomaniR.GuerraG.MocciaF

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Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9