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Although repurposing existing drugs offers a cost-effective and time-efficient alternative for identifying new therapies, their effective concentrationsmeasured as the half-maximal inhibitory concentration (IC50)often exceed the maximum safe plasma levels in humans, creating a major barrier to clinical application

The effect remained after weight matching [35]

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The wide distribution of CTGF across various ocular structures, combined with its presence in the AH means that CTGF is transported to the TM, where it may alter outflow resistance, ultimately impacting IOP homeostasis