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In: AIP Conference Proceedings, vol 1

I tried a lot of things like skincare etc

Prior to metabolism in the mitochondria, the acetyl group is transferred to coenzyme A (CoA) to form acetyl-CoA, which enters the TCA cycle to generate ATP through oxidative phosphorylation

These three biological states appear to be able to influence one another in a self-sustaining cycle (Nguyen et al., 2011) forming a neurotoxic triad. Figure 1 illustrates the self-sustaining interaction between excitotoxicity, oxidative stress, and inflammation (which are reviewed below), while also presenting some nutritional deficiencies which can fuel the triad