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It is tempting to speculate that low vitamin C availability is necessary whenever cell metabolism must be downregulated, as in seeds or in the quiescent center of the root apical meristem, where AsA is apparently leashed by AsA oxidase ( via the demethylation of DNA and histone proteins catalyzed by TET dioxygenases has been reported (Young et al., 2015)

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In PAH models and patients with left heart disease-related PH, macrophages are elevated, along with increased lung IL-6 levels (Kherbeck et al., 2013)

CKD stage was based on the estimated glomerular filtration rate (GFR), determined using the CKD-EPI equation

[DOI] [PMC free article] [PubMed] [Google Scholar] 44.Buckley M.C., Kumar A., Swaminath A