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Additionally, excessive copper can disturb intracellular calcium ion homeostasis, which is critical for noemal ER function

4.1.2 Function of curcumin in AD The strategies of curcumin to address AD mainly include the inhibition of A aggregation and tau hyperphosphorylation, anti-oxidation, anti-inflammation and brain-gut axis regulation (Pei et al., 2024

In an ACLT induced rat model, systemic distribution was minimal and no significant in vivo toxicity was observed, indicating favorable radiologic safety (Liu P

Given that the authors found that the top 10 key target proteins were markedly enriched in the cellular senescence pathways, they further used molecular docking to verify that the cellular senescence marker proteins p53, p21 and p16 are potential binding targets of AS-IV

D., et al., Homocysteine and alpha-lipoic acid regulate p44/42 MAP kinase phosphorylation in NIH/3T3 cells