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Platinum-based chemotherapy agents may induce an increase in NAD + -dependent deacetylase SIRT1 ( 2.6 Potential of metformin As a classic treatment for diabetes, metformin may play a therapeutic role by exploiting the metabolic changes of platinum-resistant ovarian cancer, which is conducive to the cytotoxic effect of platinum drugs and prevents the progression of tumor cells

J Am Coll Nutr (2005) 24(6):48693

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