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469 The mitochondrial protein sideroflexin 1 (SFXN1) is responsible for importing iron from the cytoplasm to the mitochondria, and SFXN1 deficiency leads to mitochondrial respiratory chain damage, affecting the biogenesis and assembly of complex III

22 Conditions such as aging, hypertension, ischemic heart disease, diabetes, and chronic lung disease are associated with decreased baseline GSH levels, while smoking, obesity, alcoholism, renal failure, cancers, and other chronic diseases are linked to disruptions in GSH homeostasis, impairing glutathione functionality

doi:10.1016/j.brainres.2010.11.078

So really there's two tenets of therapy