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1 Pulmonary vasoconstriction, pulmonary vascular remodeling (PVR), and in situ thrombosis formation are the main pathological changes in PH, and they are primarily associated with impaired pulmonary vascular endothelial function caused by an imbalance between vasodilators and vasoconstrictors (nitric oxide [NO]/endothelin-1 [ET-1]), 11 abnormal PASMC proliferation, local inflammation accumulation, immune dysregulation, mitochondrial dysfunction, and metabolic reprogramming, among other factors

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Floyd RA, Hensley K (2002) Oxidative stress in brain aging

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