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However, targeting specific gut microbiota with antifungals often yields unsatisfactory results, as some drugs are rapidly metabolized and fail to reach the lower digestive tract 167

In mice, SFB can protect the host by promoting colonization resistance against a wide array of pathogens in the gut 3,97 and more recently also in the lung 12,13,98 while also exacerbating disease severity in models including autoimmune encephalitis 18 , obesity-induced liver damage 19 , autoimmune arthritis 17,20 , depression 42 , Crohns disease 15 , and autism 16

doi:10.1016/j.neuropharm.2009.07.027 1059. Prodan-Brbulescu C, Alin CD, Faur IF, Bujor GC, eclman EP, Entescu V, Dnil AI, Descu E, Hajjar R, Ghenciu LA, et al