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Specifically, in male patients with GBA1 mutations, robust volcano-plot analysis revealed decreased levels of L-glutamic acid, L-alanine, choline, malonate, acetic acid, and pyruvic acid, coupled with upregulation of L-methionine and 3-hydroxybutyric acid compared with control subjects

However, these findings were derived from heterogeneous models with inconsistent dosing regimens and variable outcome definitions (Cerovecki et al

Sorafenib stimulates NRF2 expression in HCC cells, which boosts MT-1G expression, which prevents ferroptosis by inhibiting GSH depletion, which is one of the pathways associated in sorafenib resistance (87)

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Research has found that resveratrol benefits endothelial function, blood vessel health and blood pressure by boosting SIRT1 activity, reducing oxidative stress and increasing nitric oxide production