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TAMs adjust their activation state, synthesis of inflammatory cytokines, and proliferation of peroxisomes by modulating glutamine metabolism [123]

In terms of angiogenesis, MenSC-Exos dose-dependently upregulated key angiogenic markers, including vascular endothelial growth factor A (VEGFA), CD31, and von Willebrand factor (vWF), with 10 g of MenSC-Exos demonstrating tenfold greater efficacy than exosomes from other stem cell sources (Dalirfardouei et al., 2019

Research shows that MOTS-c activates the AMPK pathway, which regulates cellular energy balance and helps restore metabolic stability under stress conditions