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Downregulation or deficiency of pyruvate kinase leads to ATP depletion which in turn affects cell viability as well as accumulation of the glycolytic intermediates (2,3-diphosphoglycerate (2,3-DPG) that eventually leads to impaired glycolytic flux 46

Its neuropathological hallmarks include amyloid-beta (A) plaque deposition, NFTs composed of hyperphosphorylated tau protein, cerebral amyloid angiopathy, neuroinflammation, and progressive neurodegeneration (284)

Primary GCs in follicular fluid (FF) were collected, and one or two embryos were transferred on day 3 or day 5 following oocyte retrieval

In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia