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TGF-beta pathway activation organizes the actin cytoskeleton in fibroblasts, restoring collagen contraction and remodeling capacity

The Review then highlights recently discovered mechanisms, including post-translational modifications and metabolic pathways such as amino acid availability and the circadian clock, that modulate ECM secretion, assembly and remodelling in homeostasis and human diseases

Differential expression in RNA-seq: a matter of depth

Elastin, which the body largely stops producing after puberty, gradually fragments and loses its recoil properties