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Additionally, even though Nrf2 activation was seen in vivo , aldosterone-treated rat kidneys showed significant DNA damage, showing that the response was insufficient to shield the animals from these side effects (75)

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Originally described by Hoffmann et al

A significant reduction in phagocytic activity and enhanced production of reactive oxygen species, defective neutrophil amplification and attenuated pro-inflammatory cytokine responses of monocytes after bacterial stimulation are all distinctive features of innate responses especially pronounced in preterm infants (38, 43, 45)