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Several studies confirm that long-term treatment with non-steroidal anti-inflammatory drugs (NSAIDs) that non-selectively inhibit cyclooxygenases COX-1 and COX-2, such as ibuprofen, reduce the risk of AD by the inhibition of the inflammatory cascade [13,14,15]

D., Bedaiwy, M

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A., Ziegler, M

Indeed, lenabasum treated monocyte-derived macrophages from cystic fibrosis patients expressed decreased markers of activation, secreted lower amounts of pro-inflammatory cytokines and had higher bacterial killing activity when compared to untreated cells (Tarique et al., 2020)