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Useful video references that were part of this discussion at the time include: video 1 and video 2

Chatzimitakos, T., Athanasiadis, V., Kotsou, K., Mantiniotou, M., Kalompatsios, D., Makrygiannis, I.,..., & Lalas, S

Additionally, Protein kinase C (PKC) pathway activation can induce insulin receptor substrate 1 (IRS-1) phosphorylation, inhibiting insulin signaling through downstream effectors such as Akt, phosphoinositide 3-kinase (PI3K), and glucose transporter 4 (GLUT-4) (Ritter et al., 2015

Zimbone S, Monaco I, Gian F, Pandini G, Copani AG, Giuffrida ML, Rizzarelli E (2018) Amyloid Beta monomers regulate cyclic adenosine monophosphate response element binding protein functions by activating type-1 insulin-like growth factor receptors in neuronal cells