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NOCs can lead to DNA alkylation, which can induce genetic mutations that ultimately lead to cancer ( 2 S, which can promote the occurrence of CRC by inhibiting butyrate oxidation, destroying the intestinal barrier, and interacting with ROS to induce DNA damage ( Dietary fiber can increase intestinal peristalsis, promote stool excretion, and reduce the food transit time in the colon, thus reducing the contact time of potential carcinogens with intestinal mucosa ( 2.1.2 Familial inheritance Approximately 20-30% of CRC cases are associated with genetic factors, 2-5% of CRC is caused by inherited syndrome, mainly including Lynch syndrome, familial adenomatous polyposis, juvenile polyposis syndrome, MUTYH -associated polyposis, and Peutz-Jeghers syndrome etc ( 2.1.3 Polyps The incidence of CRC is closely related to polyps

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Studies have found that HBOT can improve the common pathological angiogenesis of RA, and its mechanism is mainly through promoting the expression of PHD2, accelerating the degradation of HIF-1, and inhibiting the production of angiogenic factor VEGFA (147)

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